Jeu Chimie is played by two contestants who alternatively place points on the empty spots of the game's grid (by double-tapping the grid).

The game's objective is to capture the opponent's points by circling them. It is not allowed to capture your own points. It is possible to capture the plot of your opponent; when this happens the points won by the captured plot are lost.

The game is completed when either a winning score is reached or when the play time is over. The player with the highest score wins.