The guidelines contained in this application are designed to
provide extensive easy-to-read information regarding the
dialyzability of drugs. Numerous literature sources have been used
in preparing the guidelines. For many drugs including
newly-approved medications investigational agents and medications
available in other countries there have been no dialysis
pharmacokinetic studies. In some cases the available data may
conflict. Conditions of dialysis used in published studies may not
reflect current dialysis practice and technology. Variations in the
duration of dialysis blood and dialysate flow rates dialysis
membranes and whether peritoneal dialysis is continuous or
intermittent will all affect drug removal. These guidelines
distinguish between conventional hemodialysis and high permeability
(high-flux) hemodialysis where such data are available. No
information is provided on drug dialyzability with continuous renal
replacement therapy (CRRT) or with plasmapheresis. For additional
information on specific drugs the reader should consult the primary
literature.
Users of this application are referred to www.renalpharmacyconsultants.com for background and explanatory material to assist in the interpretation of the tabular data. The website provides specific information about factors that influence drug dialyzability and special considerations such as CRRT plasmapheresis and drugs of abuse. Users must be familiar with this information prior to using the content of this application. The website also includes a table presenting sieving coefficient data from in vitro and in vivo evaluations which can be used to predict dosing requirements in CRRT and a table regarding removal of drugs of abuse.
Users of this application are referred to www.renalpharmacyconsultants.com for background and explanatory material to assist in the interpretation of the tabular data. The website provides specific information about factors that influence drug dialyzability and special considerations such as CRRT plasmapheresis and drugs of abuse. Users must be familiar with this information prior to using the content of this application. The website also includes a table presenting sieving coefficient data from in vitro and in vivo evaluations which can be used to predict dosing requirements in CRRT and a table regarding removal of drugs of abuse.
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